Major Depressive Disorder In The Elderly

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00093288
First received: October 5, 2004
Last updated: August 30, 2012
Last verified: August 2012
  Purpose

This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).


Condition Intervention Phase
Depressive Disorder, Major
Major Depressive Disorder (MDD)
Drug: bupropion XL
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Multi-Centre, Randomised, Double-Blind, Parallel-Group, Placebo-Controlled, Flexible Dose Study to Evaluate the Efficacy, Safety and Tolerability of Extended-release Bupropion Hydrochloride (150mg-300mg Once Daily) in Elderly Subjects With Major Depressive Disorder

Resource links provided by NLM:


Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Montgomery-Asberg Depression Rating Scale

Secondary Outcome Measures:
  • Montgomery-Asberg Depression Rating Scale Clinical Global Impression Improvement Scale Clinical Global Impression Severity Scale Hamilton Anxiety Rating Scale

Estimated Enrollment: 364
Study Start Date: June 2004
Intervention Details:
    Drug: bupropion XL
    Other Name: bupropion XL
  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Primary diagnosis of Major Depressive Disorder with DSM-IV criteria for their current episode for at least 8 weeks.

Exclusion Criteria:

  • Patient has current or past history of seizure disorder or brain injury.
  • Patient has a diagnosis of anorexia or bulimia within the past 12 months.
  • Patient has a past or current DMS-IV diagnosis of schizophrenia or any other psychotic disorder(s).
  • Patient has had a myocardial infarction within 1 year or a history of uncontrolled hypertension or unstable heart disease with 6 months.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00093288

  Hide Study Locations
Locations
United States, California
GSK Investigational Site
Oceanside, California, United States, 92056
GSK Investigational Site
San Marino, California, United States, 91108
GSK Investigational Site
Temecula, California, United States, 92591
United States, Colorado
GSK Investigational Site
Colorado Springs, Colorado, United States, 80904
United States, Connecticut
GSK Investigational Site
Norwich, Connecticut, United States, 06360
United States, Florida
GSK Investigational Site
Hialeah, Florida, United States, 33016
GSK Investigational Site
Miami, Florida, United States, 33125
GSK Investigational Site
Orlando, Florida, United States, 32806
GSK Investigational Site
Sarasota, Florida, United States, 34232
United States, Illinois
GSK Investigational Site
Oak Brook, Illinois, United States, 60523
United States, Louisiana
GSK Investigational Site
Shreveport, Louisiana, United States, 71101
United States, Maryland
GSK Investigational Site
Rockville, Maryland, United States, 20852
United States, New Jersey
GSK Investigational Site
Clementon, New Jersey, United States, 08021
GSK Investigational Site
Kenilworth, New Jersey, United States, 07033
GSK Investigational Site
Princeton, New Jersey, United States, 08540
United States, New York
GSK Investigational Site
Brooklyn, New York, United States, 11235
GSK Investigational Site
New York, New York, United States, 10021
GSK Investigational Site
Staten Island, New York, United States, 10305
United States, Oklahoma
GSK Investigational Site
Oklahoma City, Oklahoma, United States, 73118
United States, Tennessee
GSK Investigational Site
Memphis, Tennessee, United States, 38119
United States, Texas
GSK Investigational Site
Austin, Texas, United States, 78756
GSK Investigational Site
Richardson, Texas, United States, 75080
GSK Investigational Site
San Antonio, Texas, United States, 78229
Australia, Queensland
GSK Investigational Site
Caboolture, Queensland, Australia, 4510
GSK Investigational Site
Everton Park, Queensland, Australia, 4053
GSK Investigational Site
New Farm, Queensland, Australia, 4005
Australia, Victoria
GSK Investigational Site
Heidelberg West, Victoria, Australia, 3081
GSK Investigational Site
Malvern, Melbourne, Victoria, Australia, 3144
GSK Investigational Site
Melbourne, Victoria, Australia, 3076
GSK Investigational Site
St. Albans, Victoria, Australia, 3021
Belgium
GSK Investigational Site
Liège, Belgium, 4000
GSK Investigational Site
Mont-Godinne, Belgium, 5530
GSK Investigational Site
Montignies-sur-Sambre, Belgium, 6061
Canada, British Columbia
GSK Investigational Site
Kelowna, British Columbia, Canada, V1Y 2H4
Canada, Nova Scotia
GSK Investigational Site
Sydney, Nova Scotia, Canada, B1P 1C6
Canada, Ontario
GSK Investigational Site
Chatham, Ontario, Canada, N7L 1B7
GSK Investigational Site
Mississauga, Ontario, Canada, L5M 4N4
Croatia
GSK Investigational Site
Osijek, Croatia
GSK Investigational Site
Zagreb, Croatia, 10000
Finland
GSK Investigational Site
Espoo, Finland, 02650
GSK Investigational Site
Kuopio, Finland, 70110
GSK Investigational Site
Mikkeli, Finland, 50100
GSK Investigational Site
Pori, Finland, 28100
GSK Investigational Site
Turku, Finland, 20100
France
GSK Investigational Site
Angoulême, France, 16000
GSK Investigational Site
Arcachon, France, 33120
GSK Investigational Site
Chateau Gontier, France, 53200
GSK Investigational Site
Chatou, France, 78400
GSK Investigational Site
Cherbourg, France, 50100
GSK Investigational Site
Le Pecq, France, 78230
GSK Investigational Site
Nimes, France, 30900
GSK Investigational Site
Orvault, France, 44700
GSK Investigational Site
Paris, France, 75012
GSK Investigational Site
Strasbourg, France, 67100
GSK Investigational Site
Toulouse, France, 31000
Germany
GSK Investigational Site
Ellwangen, Baden-Wuerttemberg, Germany, 73479
GSK Investigational Site
Ulm, Baden-Wuerttemberg, Germany, 89073
GSK Investigational Site
Wuerzburg, Bayern, Germany, 97070
GSK Investigational Site
Huettenberg, Hessen, Germany, 35625
GSK Investigational Site
Achim, Niedersachsen, Germany, 28832
GSK Investigational Site
Westerstede, Niedersachsen, Germany, 26655
GSK Investigational Site
Bielefeld, Nordrhein-Westfalen, Germany, 33647
GSK Investigational Site
Bochum, Nordrhein-Westfalen, Germany, 44892
GSK Investigational Site
Bochum, Nordrhein-Westfalen, Germany, 44869
GSK Investigational Site
Hattingen, Nordrhein-Westfalen, Germany, 45525
GSK Investigational Site
Haldensleben, Sachsen-Anhalt, Germany, 39340
GSK Investigational Site
Koethen, Sachsen-Anhalt, Germany, 06366
GSK Investigational Site
Chemnitz, Sachsen, Germany, 09111
GSK Investigational Site
Dresden, Sachsen, Germany, 01097
GSK Investigational Site
Leipzig, Sachsen, Germany, 04107
GSK Investigational Site
Berlin, Germany, 13187
GSK Investigational Site
Berlin, Germany, 10629
India
GSK Investigational Site
Bangalore, India, 560034
GSK Investigational Site
Bangalore, India, 560029
GSK Investigational Site
Jaipur, India
GSK Investigational Site
Mumbai,, India, 400 008
Latvia
GSK Investigational Site
Jelgava, Latvia, LV3008
GSK Investigational Site
Riga, Latvia, LV1005
GSK Investigational Site
Strenci, Latvia, LV4730
Netherlands
GSK Investigational Site
Amersfoort, Netherlands, 3818 ES
GSK Investigational Site
Grubbenvorst, Netherlands, 5971 BB
GSK Investigational Site
Hilversum, Netherlands, 1211 PA
GSK Investigational Site
Hoogvliet, Netherlands, 3192 JN
GSK Investigational Site
Wildervank, Netherlands, 9648 BE
Norway
GSK Investigational Site
Bergen, Norway, N-5068
GSK Investigational Site
Hamar, Norway, N-2317
Poland
GSK Investigational Site
Bydgoszcz, Poland, 85-096
GSK Investigational Site
Choroszcz, Poland, 16-070
GSK Investigational Site
Torun, Poland, 87-100
Russian Federation
GSK Investigational Site
Moscow, Russian Federation, 115522
GSK Investigational Site
Moscow, Russian Federation, 119992
South Africa
GSK Investigational Site
Bloemfontein, South Africa
GSK Investigational Site
Cape Town, South Africa, 7460
GSK Investigational Site
Danville, South Africa, 0183
GSK Investigational Site
Observatory ,Cape Town, South Africa, 7925
GSK Investigational Site
Randburg, Johannesburg, South Africa, 2194
GSK Investigational Site
Somerset West, South Africa, 7140
GSK Investigational Site
Vereeniging, South Africa, 1929
Sponsors and Collaborators
GlaxoSmithKline
Investigators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

No publications provided

Responsible Party: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT00093288     History of Changes
Other Study ID Numbers: AK130940
Study First Received: October 5, 2004
Last Updated: August 30, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by GlaxoSmithKline:
MDD
bupropion
Depression

Additional relevant MeSH terms:
Depressive Disorder
Depression
Depressive Disorder, Major
Mood Disorders
Mental Disorders
Behavioral Symptoms
Bupropion
Antidepressive Agents, Second-Generation
Antidepressive Agents
Psychotropic Drugs
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions
Dopamine Uptake Inhibitors
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Uptake Inhibitors
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on June 17, 2013