Long-term Caloric Restriction and Cellular Aging Markers (CRONA)

This study has been completed.

Sponsor:

Collaborator:

Robert Wood Johnson Foundation

Information provided by (Responsible Party):

University of California, San Francisco

ClinicalTrials.gov Identifier:

NCT01256840

First received: December 2, 2010

Last updated: September 20, 2011

Last verified: September 2011

History of Changes

Tracking Information

First Received Date ^ICMJE

December 2, 2010

Last Updated Date

September 20, 2011

Start Date ^ICMJE

December 2010

Primary Completion Date

Not Provided

Current Primary Outcome Measures ^ICMJE

Telomere length [ Time Frame: One day ] [ Designated as safety issue: No ]

This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

Complete list of historical versions of study NCT01256840 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Not Provided

Original Secondary Outcome Measures ^ICMJE

Not Provided

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Long-term Caloric Restriction and Cellular Aging Markers

Official Title ^ICMJE

Caloric Restriction With Optimal Nutrition and Aging Study

Brief Summary

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Detailed Description

Not Provided

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Cohort
Time Perspective: Cross-Sectional

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples With DNA

Description:

Whole blood, serum.

Sampling Method

Non-Probability Sample

Study Population

Community sample and Calorie Restriction Society

Condition ^ICMJE

Aging

Intervention ^ICMJE

Not Provided

Study Group/Cohort (s)

Calorie Restricting Group
Normal-eating controls
Obese comparison group

Publications *

Not Provided

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Estimated Enrollment ^ICMJE

Completion Date

Not Provided

Primary Completion Date

Not Provided

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Calorie restricting group: Self-reported caloric restriction for at least two years
Calorie restriction group: BMI below 23
Normal eating control: Normal eating (no history of caloric restriction) for two years
Normal eating control: BMI below 30
Obese comparison group: BMI above 30
Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

Regular smoker for the past six months

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT Number ^ICMJE

NCT01256840

Other Study ID Numbers ^ICMJE

UCSF-CHR-10-01323

Has Data Monitoring Committee

Responsible Party

University of California, San Francisco

Study Sponsor ^ICMJE

University of California, San Francisco

Collaborators ^ICMJE

Robert Wood Johnson Foundation

Investigators ^ICMJE

Principal Investigator:

A. Janet Tomiyama, Ph.D.

University of California, San Francisco

Information Provided By

University of California, San Francisco

Verification Date

September 2011

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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