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Radiologic Features of Invasive Pulmonary Aspergillosis

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Sung-Han Kim, Asan Medical Center
ClinicalTrials.gov Identifier:
NCT01178177
First received: August 9, 2010
Last updated: May 14, 2013
Last verified: May 2013
History of Changes

August 9, 2010
May 14, 2013
January 2008
February 2010   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT01178177 on ClinicalTrials.gov Archive Site
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Radiologic Features of Invasive Pulmonary Aspergillosis
Retrospective Analysis of Radiologic Features of Invasive Pulmonary Aspergillosis in Transplant Recipients and Neutropenic Patients.Transplant Recipients and Neutropenic Patients

Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.
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Observational
Observational Model: Cohort
Time Perspective: Retrospective
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Probability Sample

All adult patients who are diagnosed with invasive pulmonary aspergillosis (IPA)between January 2008 and February 2010.
  • Hematologic Disease
  • Solid Organ Transplantation
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  • SOT recipients
    solid organ transplant recipients with invasive pulmonary aspergillosis
  • Hematologic disease
    Hematologic disease patients with invasive pulmonary aspergillosis
Park SY, Lim C, Lee SO, Choi SH, Kim YS, Woo JH, Song JW, Kim MY, Chae EJ, Do KH, Song KS, Seo JB, Kim SH. Computed tomography findings in invasive pulmonary aspergillosis in non-neutropenic transplant recipients and neutropenic patients, and their prognostic value. J Infect. 2011 Dec;63(6):447-56. doi: 10.1016/j.jinf.2011.08.007. Epub 2011 Aug 16.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
130
February 2010
February 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • IPA cases with solid organ transplant recipients and hematologic disease patients
  • proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria

Exclusion Criteria:

  • under 16 years old
  • possible cases of invasive pulmonary aspergillosis
Both
16 Years and older
No
Contact information is only displayed when the study is recruiting subjects
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NCT01178177
IPA -HEM vs SOT-2010
Yes
Sung-Han Kim, Asan Medical Center
Asan Medical Center
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Study Chair: Sung-Han Kim, MD Department of Infectious Diseases, Asan Medical Center
Asan Medical Center
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP