Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus

Nitazoxanide has proved an cytoprotective effect against rotavirus infection. How it could be clinically important in time of hospitalization and reduction of duration of diarrhea secondary to rotavirus?

Nitazoxanide has demonstrated a cytoprotective effect against rotavirus, reducing duration time of diarrhea in comparison to placebo in previous studies. In the current study, based in those results, we design a randomized single-blind controlled trial, in order to asses the effectiveness of nitazoxanide and probiotics in comparison with a control group

• Diarrhea
• Rotavirus Infection

• Drug: Nitazoxanide
  Nitazoxanide 15mg/Kg/day twice day for 3 days
  Other Name: Noxom; Givotan
• Drug: Probiotic mix preparation
  Probiotic preparation 1 gram twice a day for 5 days
  Other Name: Probiotic
• Other: Oral hydration solutions
  Oral hydration solutions as needed
  Other Names:

  • Rehsal 60
  • 2.5% Glucosaline

• Active Comparator: 1
  This group will receive oral nitazoxanide preparation
  Intervention: Drug: Nitazoxanide
• Active Comparator: 2
  This group will receive a mix combination of probiotics
  Intervention: Drug: Probiotic mix preparation
• Placebo Comparator: 3
  This is the control group receiving only oral or systemic hydration solutions
  Intervention: Other: Oral hydration solutions

Inclusion Criteria:

• Positive stool sample for rotavirus test

Exclusion Criteria:

• Severe malnourishment
• Severe dehydration
• History of diarrhea more than 3 days previous hospitalization
• Use of antibiotics, probiotics or nitazoxanide 3 weeks before admission
• Systemic infections
• Severe chronic disease
• Mixed enteric infections besides rotavirus