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Epidemiology and Clinical Presentation of H1N1 Infection in Children in Geneva

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Klara M. Pósfay Barbe, University Hospital, Geneva
ClinicalTrials.gov Identifier:
NCT01022931
First received: November 30, 2009
Last updated: December 10, 2012
Last verified: December 2012
History of Changes
  Purpose

This study aims to identify clinical symptoms and outcomes, as well as response to anti-viral treatment in children living in Geneva, with influenza A/ H1N1 infection during the current pandemic.


Condition
Healthy
Immunosuppressed
Asthmatic
Neuromuscular Diseases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of a New Virus(Influenza A H1N1/09) in Children: Epidemiology, Clinical Presentation and Outcome, and Response to Treatment

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Geneva:

Primary Outcome Measures:
  • ABCB1 polymorphisms [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    ABCB1 gene polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia


Biospecimen Retention:   Samples With DNA

Nasal swab; DNA for genetic polymorphisms (Response to oseltamivir)


Enrollment: 200
Study Start Date: October 2009
Study Completion Date: July 2012
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   up to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Children seen at the emergency ward

Criteria

Inclusion Criteria:

  • suspicion of H1N1 infection

Exclusion Criteria:

  • Not available for a 30 days follow-up
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01022931

Locations
Switzerland
Children's Hospital of Geneva, HUG
Geneva, GE, Switzerland, 1211
Sponsors and Collaborators
University Hospital, Geneva
Investigators
Principal Investigator: Klara M Posfay-Barbe, MD, MS University Hospitals of Geneva
  More Information

No publications provided

Responsible Party: Klara M. Pósfay Barbe, Head of Pediatric Infectious Diseases, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT01022931     History of Changes
Other Study ID Numbers: H1N1epidemiology
Study First Received: November 30, 2009
Last Updated: December 10, 2012
Health Authority: Switzerland: Laws and standards

Keywords provided by University Hospital, Geneva:
Influenza A H1N1
Children
Epidemiology
 Treatment
Oseltamivir
Genetics

Additional relevant MeSH terms:
Asthma
Neuromuscular Diseases
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
 Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on June 18, 2013