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Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma

This study is currently recruiting participants.
Verified February 2013 by University of Arizona
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
University of Arizona
ClinicalTrials.gov Identifier:
NCT00900341
First received: May 9, 2009
Last updated: February 14, 2013
Last verified: February 2013
History of Changes
  Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.


Condition Intervention
Sarcoma
 Genetic: DNA analysis
Genetic: gene expression analysis
Genetic: protein expression analysis
Genetic: reverse transcriptase-polymerase chain reaction
Genetic: western blotting
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: LABORATORY STUDIES OF SOFT TISSUE SARCOMAS

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: August 2005
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
  • To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
  • To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
  • To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.

OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients undergoing surgical treatment for soft tissue sarcomas removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes.

Criteria

DISEASE CHARACTERISTICS:

  • Meets one of the following criteria:

    • Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or follow-up at the Arizona Cancer Center or University Medical Center
    • Patients undergoing surgical treatment for STS removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00900341

Locations
United States, Arizona
Arizona Cancer Center at University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724-5024
Contact: Lee D. Cranmer, MD, PhD     866-278-1554        
Sponsors and Collaborators
University of Arizona
National Cancer Institute (NCI)
Investigators
Principal Investigator: Lee D. Cranmer, MD, PhD University of Arizona
  More Information

Additional Information:
Clinical trial summary from the National Cancer Institute's PDQ® database  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: University of Arizona
ClinicalTrials.gov Identifier: NCT00900341     History of Changes
Other Study ID Numbers: 05-0509-04, P30CA023074, UARIZ-HSCA0535, UARIZ-17879
Study First Received: May 9, 2009
Last Updated: February 14, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by University of Arizona:
adult soft tissue sarcoma
childhood soft tissue sarcoma

Additional relevant MeSH terms:
Sarcoma
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms

ClinicalTrials.gov processed this record on May 23, 2013