Heart Rate Variability in Chronic Kidney Disease Patients
Recruitment status was Active, not recruiting
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Purpose
Use 24hr Holter ECG, ultrasound and cardiac fibrosis markers in the chronic kidney disease patients
| Condition |
|---|
|
Chronic Kidney Disease Heart Rate Variability |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
| Official Title: | Heart Rate Variability in Chronic Kidney Disease Patients |
- heart rate variability, heart function, PET, Kt/V [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples Without DNA
PD effluent and blood sample
| Estimated Enrollment: | 300 |
| Study Start Date: | December 2009 |
| Estimated Study Completion Date: | September 2010 |
| Estimated Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
250~300 patients
heart rate variability, heart function and Kt/V
|
Detailed Description:
24hr Holter examination is a non-invasive tool in detecting and diagnosing cardiac arrhythmia. Moreover, Heart rate variability has been proven to been an important prognostic factor in many cardiovascular diseases. The traditional linear analysis of heart rate variability proved to predict clinical outcome in myocardial infarction patients. The more delicate non-linear analysis in heart rate variability is one of the hot topics in the world.
Despite some biochemical values like WBC counts, platelet counts, BUN, creatinine, lactate, clinical vital parameters like blood pressure, heart rate, and oxygenation have been used to predict clinical outcome in chronic renal disease(CKD) patients, the application is still limited. It is an international interest to find a more safe and simple technique to identify important prognostic factors in CKD patients. Our project aimed to recruit these CKD patients from our hospital and conduct a cross-sectional study. Cardiac ultrasonography and 24hrs Holter will be arranged. Linear and non-linear analysis of heart rate variability will be performed and serum marker that influence prognosis like WBC count, platelet count, lactate, BUN, creatinine, fibrosis marker and adiponectin will be checked. Short term and long term outcome was followed and identify important prognostic factors to improve and detect clinical prognosis.
Eligibility| Ages Eligible for Study: | 15 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
peritoneal dialysis: peritoneal dialysis patient lasting for more than 3 months
Inclusion Criteria:
- peritoneal dialysis more than 3 months
Exclusion Criteria:
- pregnancy 2. received CT in recent 3 months
Contacts and Locations More Information
No publications provided
| Responsible Party: | Jenq-Wen Huang, National Taiwan University Hospital |
| ClinicalTrials.gov Identifier: | NCT00824577 History of Changes |
| Other Study ID Numbers: | 200812010R |
| Study First Received: | January 16, 2009 |
| Last Updated: | June 28, 2010 |
| Health Authority: | Taiwan: Department of Health |
Keywords provided by National Taiwan University Hospital:
|
heart rate variability autonomic function heart function |
Additional relevant MeSH terms:
|
Kidney Diseases Renal Insufficiency, Chronic Kidney Failure, Chronic Urologic Diseases Renal Insufficiency |
ClinicalTrials.gov processed this record on June 17, 2013