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Transcranial Magnetic Stimulation (TMS) for Treatment of Auditory Hallucinations

This study has been completed.
Sponsor:
Collaborators:
NSW Schizophrenia Fellowship
Rebecca Cooper Medical Research Foundation
Information provided by:
The University of New South Wales
ClinicalTrials.gov Identifier:
NCT00763841
First received: September 30, 2008
Last updated: January 19, 2010
Last verified: November 2009
History of Changes
  Purpose

Transcranial magnetic stimulation (TMS) involves the use of magnetic fields to non-invasively stimulate the brain. Studies overseas have suggested this may be an effective and safe treatment for auditory hallucinations in patients with schizophrenia. This is a sham-controlled, double-blind trial of TMS stimulation for the treatment of auditory hallucinations in patients with schizophrenia.


Condition Intervention Phase
Auditory Hallucinations
 Device: Transcranial magnetic stimulation
Device: Sham
 Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Pilot Study Using Transcranial Magnetic Stimulation (TMS) to Investigate the Role of the Temporal Cortex in Schizophrenic Patients With Auditory Hallucinations

Resource links provided by NLM:

MedlinePlus related topics: Schizophrenia
U.S. FDA Resources

Further study details as provided by The University of New South Wales:

Primary Outcome Measures:
  • Daily Voices Ratings (Mental Health Research Institute, Victoria) [ Time Frame: Daily ] [ Designated as safety issue: No ]

Estimated Enrollment: 18
Study Start Date: September 1999
Study Completion Date: September 2008
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Stimulation will be given daily at a particular site for three days a week
 Device: Transcranial magnetic stimulation
Stimulation will be given daily at a particular site for three days a week
Sham Comparator: 2 Device: Sham

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Over 18, with DSM-IV diagnosis of Schizophrenia and auditory hallucinations of clear external origins, refractory to pharmacotherapy and occurring at least 5 times per day.

Exclusion Criteria:

  • Subjects with contraindications to TMS (e.g. epilepsy, pacemaker) or those with an unacceptably high risk (e.g. suicide risk) will be excluded from the study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00763841

Locations
Australia, New South Wales
School of Psychiatry
Sydney, New South Wales, Australia, 2031
Sponsors and Collaborators
The University of New South Wales
NSW Schizophrenia Fellowship
Rebecca Cooper Medical Research Foundation
Investigators
Principal Investigator: Colleen Loo, MBBS, FRANZCP. MD University of NSW
  More Information

No publications provided

Responsible Party: Assoc. Prof. Colleen Loo, University of NSW
ClinicalTrials.gov Identifier: NCT00763841     History of Changes
Other Study ID Numbers: 07019
Study First Received: September 30, 2008
Last Updated: January 19, 2010
Health Authority: Australia: Human Research Ethics Committee

Keywords provided by The University of New South Wales:
Auditory hallucinations

Additional relevant MeSH terms:
Hallucinations
Perceptual Disorders
Neurobehavioral Manifestations
 Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on May 16, 2013